Preheat oven: Heat oven to 375°F (190°C). Lightly grease a loaf pan or line with parchment.
Mix breadcrumbs and milk: In a large bowl, stir breadcrumbs with milk and let sit for 5 minutes until softened.
Prepare meatloaf mixture: Add ground meat, egg, onion, garlic, parsley, thyme, Worcestershire, salt, and pepper. Mix gently with hands or a spoon until just combined—avoid overmixing to keep the meatloaf tender.
Shape & transfer: Shape mixture into a loaf and place in the prepared pan (or on a parchment-lined baking sheet for a free-form loaf).
Make the glaze: In a small saucepan over medium heat, combine cranberry sauce, ketchup, mustard, brown sugar, and vinegar. Cook for 3–5 minutes, stirring, until smooth and glossy.
Bake with glaze: Spread half the glaze over the meatloaf. Bake for 40 minutes. Remove from oven, spread remaining glaze on top, and return to bake another 15–20 minutes, until internal temperature reaches 160°F (71°C).
Rest & serve: Let meatloaf rest for 10 minutes before slicing. Serve with extra glaze on the side.